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In a new review, we reported the identification and also the characterization of a different atypical opioid receptor with unique unfavorable regulatory Attributes in the direction of opioid peptides.one Our outcomes confirmed that ACKR3/CXCR7, hitherto often known as an atypical scavenger receptor for chemokines CXCL12 and CXCL11, is also a wide-s